Recent Advancements of Nanotechnology-Based Strategies for Overcoming Tumor Microenvironment Hypoxia

Recent Advancements of Nanotechnology-Based Strategies for Overcoming Tumor Microenvironment Hypoxia

Blog Article

Hypoxia is a typical characteristic of most solid malignancies, which has multiple effects on malignant phenotypes and biological behaviors of tumors including epithelial-mesenchymal-transition (EMT), invasion, migration, metastasis, autophagy, stem cell maintenance, 92-95 civic k-swap mounts pathological angiogenesis, drug resistance, and immunosuppression.Rcentlyumoand reversing the tumor hypoxic environment via nanotechnology has emerged as a novel therapeutic approach for the treatment of malignancies.The main strategies related to nanotechnology to alleviate or ameliorate hypoxic environment are as follows: (1) Bringing external oxygen to tumor hypoxic microenvironment; (2) Generating oxygen based on nanotechnology in situ; (3) Regulating the structure of the tumor microenvironment; berkley power worm 100 pack (4) Decreasing oxygen consumption in the tumor microenvironment.In this review, we will discuss these nanotechnologies in detail.